Author

Daryl Shern Lim

Agency for Science, Technology and ResearchORCID 0000-0002-0489-4852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Choong Tat KengiD· 2 shared Ke GuoiD· 2 shared Wei Leong ChewiD· 2 shared Amine MelianiiD· 1 shared Bolun WangiD· 1 shared Kimberle Shen· 1 shared Kok Hao CheniD· 1 shared Michelle Gek Liang LimiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Choong Tat KengORCID

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2 papers

Recent·Most cited

Spatial Perturb-Seq: Single-Cell Functional Genomics within Intact Tissue Architecture

Kimberle Shen, Wan Yi Seow, Choong Tat Keng, Michelle Gek Liang Lim, Daryl Shern Lim, Ke Guo, Amine Meliani, Muhammad Irfan Bin Hajis, Bolun Wang, Shyam Prabhakar, Kok Hao Chen, Wei Leong Chew

This paper introduces Spatial Perturb-Seq, a CRISPR-based method to screen genes in intact tissues, revealing gene effects on neuronal communication in mouse brains.

Nature Communications · Feb 21, 2026Peer-reviewedCell Biology

Multiplex viral tropism assay in complex cell populations with single-cell resolution

Choong Tat Keng, Ke Guo, Daryl Shern Lim, Wei Leong Chew

The paper develops a method to measure transduction efficiency and specificity of viral vectors in complex cell populations using single-cell RNA sequencing.

bioRxiv · Jul 12, 2021 · PreprintSynthetic Biology