Author

Wan Yi Seow

Agency for Science, Technology and ResearchORCID 0000-0002-8438-048XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kok Hao CheniD· 3 shared Jeeranan BoonruangkaniD· 2 shared Nigel ChouiD· 2 shared Shyam PrabhakariD· 2 shared Amine MelianiiD· 1 shared Bolun WangiD· 1 shared Choong Tat KengiD· 1 shared Daryl Shern LimiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Kok Hao ChenORCID

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3 papers

Recent·Most cited

Spatial Perturb-Seq: Single-Cell Functional Genomics within Intact Tissue Architecture

Kimberle Shen, Wan Yi Seow, Choong Tat Keng, Michelle Gek Liang Lim, Daryl Shern Lim, Ke Guo, Amine Meliani, Muhammad Irfan Bin Hajis, Bolun Wang, Shyam Prabhakar, Kok Hao Chen, Wei Leong Chew

This paper introduces Spatial Perturb-Seq, a CRISPR-based method to screen genes in intact tissues, revealing gene effects on neuronal communication in mouse brains.

Nature Communications · Feb 21, 2026Peer-reviewedCell Biology

Guidestar: a spike-in approach to improve RNA detection accuracy in imaging-based spatial transcriptomics

Jazlynn Xiu Min Tan, Lurong Wang, Wan Yi Seow, Jeeranan Boonruangkan, Mike Huang, Jiamin Toh, Kok Hao Chen, Nigel Chou

Guidestar improves RNA detection accuracy in spatial transcriptomics by using spike-in controls to assess and enhance decoding algorithms.

bioRxiv · Jan 9, 2025 · PreprintGenomics

Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes

Xinrui Zhou, Wan Yi Seow, Norbert Ha, Teh How Cheng, Lingfan Jiang, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen

FISHnCHIPs enables highly sensitive spatial transcriptomics by imaging multiple co-expressed genes, revealing spatial gene expression patterns in tissues with improved sensitivity and coverage.

Nature Communications · Mar 15, 2024Peer-reviewedGenomics