Kok Hao Chen

This paper introduces Spatial Perturb-Seq, a CRISPR-based method to screen genes in intact tissues, revealing gene effects on neuronal communication in mouse brains.

Guidestar improves RNA detection accuracy in spatial transcriptomics by using spike-in controls to assess and enhance decoding algorithms.

The paper introduces RAMFISH, a workflow for spatial mRNA profiling in tissues, and validates it on butterfly and zebrafish samples.

FISHnCHIPs enables highly sensitive spatial transcriptomics by imaging multiple co-expressed genes, revealing spatial gene expression patterns in tissues with improved sensitivity and coverage.

BANKSY integrates cell type clustering and tissue domain segmentation using spatial transcriptomic data, identifying novel niche-dependent cell states in mouse brain regions.