Author

Ke Guo

Agency for Science, Technology and ResearchORCID 0000-0001-5681-2049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Choong Tat KengiD· 2 shared Daryl Shern LimiD· 2 shared Wei Leong ChewiD· 2 shared Amine MelianiiD· 1 shared Bolun WangiD· 1 shared Kimberle Shen· 1 shared Kok Hao CheniD· 1 shared Michelle Gek Liang LimiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Choong Tat KengORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedFeb 21, 2026

Spatial Perturb-Seq: Single-Cell Functional Genomics within Intact Tissue Architecture

Kimberle Shen, Wan Yi Seow, Choong Tat Keng…·Wei Leong Chew

This paper introduces Spatial Perturb-Seq, a CRISPR-based method to screen genes in intact tissues, revealing gene effects on neuronal communication in mouse brains.

23 citationstop 1%

mousescRNA-seq

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintJul 12, 2021

Multiplex viral tropism assay in complex cell populations with single-cell resolution

Choong Tat Keng, Ke Guo, Daryl Shern Lim, Wei Leong Chew

The paper develops a method to measure transduction efficiency and specificity of viral vectors in complex cell populations using single-cell RNA sequencing.

DOI 10.1101/2021.07.12.451549

humanscRNA-seq

𝕏 PostBluesky