Author

Herbert Guimarães de Sousa Silva

Instituto ButantanORCID 0000-0002-0491-3419Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

Júlia Pinheiro Chagas da CunhaiD· 3 shared Matthew K. WaldoriD· 2 shared 木村聡iD· 2 shared Ana Paula C. A. LimaiD· 1 shared Ana Paula de Jesus MenezesiD· 1 shared Ariel Mariano SilberiD· 1 shared Claudia RabuffoiD· 1 shared Danielle Bruno de CarvalhoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Júlia Pinheiro Chagas da CunhaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular BiologyPLoS PathogensPeer-reviewedMay 26, 2026

Remodeling of tRNA modification in Trypanosoma cruzi life forms

Herbert Guimarães de Sousa Silva, Janaina F. Nascimento, Marilene Souza Braga…·木村聡

This study profiles tRNA modifications in different life stages of Trypanosoma cruzi and finds that hydroxywybutosine modification levels regulate metacyclogenesis.

3 citationstop 2%

experimental assay

𝕏 PostBluesky

GenomicsbioRxivPreprintSep 26, 2025

First Genome-Wide Centromere Map of Trypanosoma cruzi Reveals Linear and 3D Compartment Boundaries and Spatial Clustering

Natália Karla Bellini, Pedro Gabriel Nachtigall, Pedro Leonardo Carvalho de Lima…·Júlia Pinheiro Chagas da Cunha

The paper generates a high-quality genome assembly and centromere map for T. cruzi using Hi-C and ChIP-seq, revealing structural boundaries and 3D clustering of centromeres.

DOI 10.1101/2025.09.26.678825

Hi-CChIP-seq

𝕏 PostBluesky

Cell BiologymBioPeer-reviewedAug 11, 2025

Integrating tDNA Epigenomics and Expression with Codon Usage Unravel an Intricate Connection with Protein Expression Dynamics in Trypanosoma cruzi

Herbert Guimarães de Sousa Silva, 木村聡, P. L. C. P. de Lima…·Júlia Pinheiro Chagas da Cunha

The paper investigates codon usage bias and its relationship with protein expression in Trypanosoma cruzi by integrating tRNA sequencing and transcriptomic data.

1 citation

humanmouse

𝕏 PostBluesky