Author

Justus Weber

Universitätsklinikum WürzburgORCID 0000-0002-4919-952XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Hermann EinseleiD· 2 shared Michael HudecekiD· 2 shared Aistė Skorupskaitė· 1 shared Alexander VisekrunaiD· 1 shared Barbara AltieriiD· 1 shared Christoph K. Stein‐ThoeringeriD· 1 shared Dirk Hans BuschiD· 1 shared Fabian FreitagiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Hermann EinseleORCID

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2 papers

Recent·Most cited

Tumour-derived glucocorticoids amplify ROR1 and are exploited with glucocorticoid-resistant ROR1 CAR-T cells

Marc Philipp Schauer, Justus Weber, Peter Spieler, Barbara Altieri, Leon Gehrke, Silviu Sbiera, Stefan Kircher, Max Kurlbaum, Matthias Kroiß, Katja Kiseljak‐Vassiliades, Margaret E. Wierman, Thomas Nerreter, Sophia Danhof, Hermann Einsele, Martin Faßnacht, , Michael Hudecek

The paper shows that tumor-derived glucocorticoids increase ROR1 expression while suppressing T cell activity, and GC-resistant CAR-T cells can overcome this by preserving ROR1 expression in tumor cells.

bioRxiv · Jan 28, 2025 · PreprintCancer Biology

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

Sarah Staudt, Fabian Nikolka, Markus Perl, Julia Franz, Noémie Leblay, Xiaoli-Kat Yuan, M. Larrayoz, Teresa Lozano, Linda Warmuth, Matthias A. Fante, Aistė Skorupskaitė, Teng Fei, Maria Bromberg, Patxi San Martín‐Úriz, Juan R. Rodríguez-Madoz, , Maik Luu

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

bioRxiv · Aug 19, 2024 · PreprintImmunology