Author

Nicolas J. Walker

Constellation Pharmaceuticals (United States)ORCID 0000-0002-0498-4356Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Albert J. VilellaiD· 1 shared Alexandra Palmer· 1 shared Ankita Singhal· 1 shared Anne C. Ferguson‐SmithiD· 1 shared Audrey VandommeiD· 1 shared Beiyuan FuiD· 1 shared Casper K. LumbyiD· 1 shared Charles A. IshakiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Albert J. VilellaORCID

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2 papers

Recent·Most cited

Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet

Coby Viner, Charles A. Ishak, James Johnson, Nicolas J. Walker, Hui Shi, Marcela K. Sjöberg-Herrera, Shu Yi Shen, Santana M. Lardo, David J. Adams, Anne C. Ferguson‐Smith, Daniel Diniz De Carvalho, Sarah J. Hainer, Timothy L. Bailey, Michael M. Hoffman

The paper develops methods to model transcription factor binding in modified DNA by expanding the DNA alphabet and adapting existing tools to handle custom alphabets, identifying modification-sensitive motifs and validating them with experimental data.

Genome biology · Jan 8, 2024Peer-reviewedBioinformatics

Accurate simultaneous sequencing of genetic and epigenetic bases in DNA

Jens Füllgrabe, Walraj S. Gosal, Páidí Creed, Sidong Liu, Casper K. Lumby, David J. Morley, Tobias W. B. Ost, Albert J. Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nicholas J. Harding, , Shankar Balasubramanian

This paper introduces a method to simultaneously sequence genetic and epigenetic bases in DNA with single-base resolution, demonstrating accuracy and versatility in human genomic and cell-free DNA samples.

Nature Biotechnology · Feb 6, 2023Peer-reviewedGenomics