LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus
Aykut Göktürk Üner, Won‐Mo Yang, Mincheol Kang, Kellen Cristina da Cruz Rodrigues, Ahmet Aydogan, Ji A Seo, Natália Ferreira Mendes, Min‐Seon Kim, Fatima Ezzahra Timzoura, Michael J. Holtzman, Maria K. Lehtinen, Vincent Prévot, Young‐Bum Kim
This study identifies LRP1 as a mediator of leptin transport across the blood-CSF barrier in the choroid plexus, coupled with the short-form leptin receptor, and shows its deletion leads to leptin resistance and obesity.
bioRxiv · Jul 3, 2023 · PreprintNeuroscience