Michael Bromley

Live 4D monitoring of fungal infection in an ex vivo model of fungal keratitis reveals enhanced efficacy of combined PACK-CXL and natamycin treatment

This study develops an ex vivo porcine corneal model to evaluate combined natamycin and PACK-CXL treatment for fungal keratitis, showing it reduces fungal burden more effectively than either treatment alone.

The pangenome of Aspergillus fumigatus highlights the dynamics of gene gain-loss over evolutionary timescales in a human fungal pathogen

This paper quantifies gene gain and loss dynamics in Aspergillus fumigatus over a century using a global pangenome, revealing slow genome evolution and lineage-specific resistance mechanisms.

The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target.

The paper identifies genes involved in sulfur metabolism in Aspergillus fumigatus during infection, highlighting ShmB as a promising antifungal target due to its essential role in virulence and structural differences from the human enzyme.

Azole resistance associated regulatory motifs within the promoter of cyp51A in Aspergillus fumigatus

The paper investigates the regulatory motifs in the cyp51A promoter of Aspergillus fumigatus that contribute to azole resistance, revealing iron-dependent and -independent roles of transcription factors.

Tracing patterns of evolution and acquisition of drug resistant Aspergillus fumigatus infection from the environment using population genomics

The paper uses population genomics to trace the evolution and environmental acquisition of drug-resistant Aspergillus fumigatus, finding evidence of resistant isolates transmitted from the environment to patients.