Fan Yang

This study shows chronic alcohol exposure leads to inflammation, DNA damage, and transposon activation in hematopoietic stem and progenitor cells, with lasting effects on myeloid bias and immune responses.

This paper designs a voltage-gated anion channel with voltage-dependent currents and chloride selectivity using de novo methods.

This study identifies id2b as a gene regulated by biomechanical forces in zebrafish hearts, showing its role in both myocardial contractility and valve formation through interactions with tcf3b and nrg1.

The paper traces the evolutionary changes in TRPM2 channel activation mechanisms across species, identifying key stages in the transition from simple to complex ligand binding and calcium gating.

This study identifies polymodal gating mechanisms in the proton-activated chloride channel using pharmacological and computational approaches.

The paper identifies a functional coupling between Slack and NaV1.6 that enhances quinidine blockade of Slack, suggesting a new approach for treating KCNT1-related epilepsy.

The paper quantifies immune-based counterselection of somatic mutations by analyzing their depletion in MHC class I-displayed peptides and shows that MHC alleles are incompletely dominant.

This paper develops a deep mutational scanning framework to map functional missense variants in human genes and applies it to four proteins, identifying pathogenic variants and showing scalability to disease genes.