Author

João M. Fernandes Neto

Oncode InstituteORCID 0000-0002-0549-8835Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

René BernardsiD· 2 shared Anja SieberiD· 1 shared Ben MorrisiD· 1 shared Cor LieftinkiD· 1 shared Daimy van der Ven· 1 shared Evert BosdriesziD· 1 shared Hester Heimans· 1 shared Katarzyna JastrzebskiiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSystems Biology

René BernardsORCID

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2 papers

Recent·Most cited

Systems BiologyiSciencePeer-reviewedJul 15, 2022

Identifying mutant-specific multi-drug combinations using Comparative Network Reconstruction

Evert Bosdriesz, João M. Fernandes Neto, Anja Sieber…·Lodewyk F.A. Wessels

The paper presents a pipeline to identify effective and selective multi-drug combinations by reconstructing mutant-specific signaling networks and predicting their impact on cell viability.

5 citations

humanproteomics

𝕏 PostBluesky

GenomicsbioRxivPreprintJul 13, 2021

Performance of large scale pooled CRISPR screens is dependent on Cas9 expression levels

João M. Fernandes Neto, Cor Lieftink, Katarzyna Jastrzebski…·Roderick L. Beijersbergen

This study shows that Cas9 expression levels significantly affect the efficiency and speed of large-scale pooled CRISPR screens, with higher Cas9 expression improving performance.

2 citations

humanCRISPR screen

𝕏 PostBluesky