Katarzyna Jastrzebski

ESGI: Efficient splitting of generic indices in single-cellsequencing data

ESGI provides a flexible framework for demultiplexing and processing single-cell sequencing data with arbitrary barcode architectures, supporting complex and emerging experimental designs.

NAC-mediated ribosome localization regulates cell fate and metabolism in intestinal stem cells

Performance of large scale pooled CRISPR screens is dependent on Cas9 expression levels

This study shows that Cas9 expression levels significantly affect the efficiency and speed of large-scale pooled CRISPR screens, with higher Cas9 expression improving performance.

Delineating feedback activity in the MAPK and AKT pathways using feedback-enabled Inference of Signaling Activity

This paper develops feedback-ISA (f-ISA) to model feedback mechanisms in signaling pathways, showing it can explain phosphorylation levels in MAPK and AKT pathways across breast cancer cell lines and conditions.