René Bernards

This study identifies PEBP1 as a biomarker for response to the PP2A inhibitor LB-100, showing that its depletion confers resistance by reducing prodrug conversion to the active metabolite endothall.

The paper shows that mitochondrial damage can induce therapy-induced senescence in GBM cells through a ROS-cGAS-STING-SASP cascade, outperforming single or dual pathway inhibitors.

This paper identifies SLC25A23 as a vulnerability in senescent cancer cells and shows that salinomycin induces immunogenic cell death, enhancing immune destruction of these cells when combined with a DR5 agonistic antibody.

The paper presents a pipeline to identify effective and selective multi-drug combinations by reconstructing mutant-specific signaling networks and predicting their impact on cell viability.

This study shows that Cas9 expression levels significantly affect the efficiency and speed of large-scale pooled CRISPR screens, with higher Cas9 expression improving performance.

This paper introduces a computational method to reconstruct signaling networks from incomplete perturbation data and identify differences between networks in sensitive and resistant cells.