PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery
Sean M. McKenna, Monika T. Gnatzy, Edith van der Nol, Femke J. Boxman, Chenlu Zhang, Xiaokang Jin, Jingming Liu, Jeroen Kortekaas, Xiaoyu Zhang, Sebastian J. Pomplun
PROXINAUT automates hit-to-degrader discovery by integrating library screening with parallel synthesis, resulting in validated degraders with improved binding affinity.
bioRxiv · Sep 23, 2026 · PreprintBioengineering