Roger K. Prichard

Critical Role of P-Glycoprotein-9 in Ivermectin Tolerance in Nematodes

This study identifies P-glycoprotein-9 as a key mediator of ivermectin resistance in nematodes by showing its role in drug efflux and demonstrating functional conservation across species.

The assessment of single nucleotide polymorphisms in the ss-tubulin genes in human soil-transmitted helminths exposed to different pressure with benzimidazole drugs

This study evaluates SNPs in β-tubulin genes of human soil-transmitted helminths to assess their association with benzimidazole resistance, finding no strong evidence for their role as resistance markers.

Genome structure and population genomics of the canine heartworm Dirofilaria immitis

This study improves the genome assembly of Dirofilaria immitis and analyzes global genetic structure to understand resistance to macrocyclic lactone drugs.

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

This study uses genome-wide analysis to show that genetic drift and soft selective sweeps, rather than strong selection, drive loss of ivermectin sensitivity in Onchocerca volvulus.