Author

Alyssa Hall

Broad InstituteORCID 0000-0002-0609-084XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Morgan ShengiD· 3 shared Zohreh FarsiiD· 3 shared Ally A. NicolellaiD· 2 shared Antia Valle-TojeiroiD· 2 shared Bryan J. SongiD· 2 shared Chuhan GengiD· 2 shared Deeksha Misri· 2 shared Hasmik KeshishianiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Morgan ShengORCID

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3 papers

Recent·Most cited

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Bryan J. Song, Yang Ge, Ally A. Nicolella, Min Jee Kwon, Bart Lodder, Kevin Bonanno, Antia Valle-Tojeiro, Nolan D. Hartley, Kira Perzel Mandell, John Adeleye, Deeksha Misri, Chuhan Geng, Sahana Natarajan, Inès Picard, Nate Shepard, , Morgan Sheng

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

Nature Communications · Nov 28, 2025Peer-reviewedNeuroscience

Altered striatal dopamine dynamics and behavior in Grin2a mutant mice, a genetic mouse model of schizophrenia

Alyssa Hall, John Jacoby, Himanshu Gangal, Ethan Rochman, Nathaniel Shephard, Bryan Song, Zohreh Farsi, Sandeep Robert Datta, Morgan Sheng, Prabhat S. Kunwar

This study examines the effects of Grin2a and Akap11 mutations on striatal dopamine dynamics and behavior in mice, revealing distinct impacts on locomotion and neural activity.

bioRxiv · Nov 24, 2025 · PreprintNeuroscience

Muti-omics characterization reveals brain-wide disruption of synapses and region- and age-specific changes in neurons and glia in Sp4 mutant mice, a genetic model of schizophrenia and bipolar disorder

Min Jee Kwon, Kira A. Perzel Mandell, Sameer Aryal, Chuhan Geng, Ally A. Nicolella, Antia Valle-Tojeiro, Sahana Natarajan, Deeksha Misri, Alyssa Hall, Bryan J. Song, Zohreh Farsi, Hasmik Keshishian, Steven A. Carr, Morgan Sheng

This study uses multi-omics analyses of Sp4 mutant mice to reveal synapse disruption and age- and region-specific neuronal and glial changes linked to schizophrenia and bipolar disorder.

bioRxiv · Oct 12, 2024 · PreprintNeuroscience