Author

Kevin Bonanno

Broad InstituteORCID 0000-0002-6712-9277Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 5 Organism:mouse· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Borislav DejanoviciD· 5 shared Hasmik KeshishianiD· 5 shared Morgan ShengiD· 5 shared Sameer AryaliD· 5 shared Steven A. CarriD· 5 shared Zohreh FarsiiD· 4 shared Bryan J. SongiD· 3 shared Ally A. NicolellaiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersNeuroscience

Borislav DejanovicORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatially resolved translational dysregulation in Grin2a+/- mouse model of schizophrenia

Mingrui Wu, Jiahao Huang, Sameer Aryal, Zohreh Farsi, Hongyu Chen, Yiming Zhou, Shuchen Luo, Wendy Xueyi Wang, Kevin Bonanno, Margaret Yin, Inès Picard, Borislav Dejanovic, Hasmik Keshishian, Steven A. Carr, Morgan Sheng, Xiao Wang

The paper uses spatial omics to analyze translational dysregulation in Grin2a+/- mice, finding gene-specific translation reductions in neurons and non-neuronal cells linked to schizophrenia pathophysiology.

bioRxiv · Dec 28, 2025 · PreprintNeuroscience

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

Bryan J. Song, Yang Ge, Ally A. Nicolella, Min Jee Kwon, Bart Lodder, Kevin Bonanno, Antia Valle-Tojeiro, Nolan D. Hartley, Kira Perzel Mandell, John Adeleye, Deeksha Misri, Chuhan Geng, Sahana Natarajan, Inès Picard, Nate Shepard, , Morgan Sheng

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

Nature Communications · Nov 28, 2025Peer-reviewedNeuroscience

Brain-region-specific changes and dysregulation of activity regulated genes in Gria3 mutant mice, a genetic animal model of schizophrenia

Wei-Chao Huang, Ryan J. Kast, Kira A. Perzel Mandell, Borislav Dejanovic, Kevin Bonanno, Sameer Aryal, Zohreh Farsi, Jonathan J. Wilde, Dongqing Wang, Xian Gao, Hasmik Keshishian, Steven A. Carr, Guoping Feng, Morgan Sheng

This study examines Gria3 mutant mice to identify transcriptomic and proteomic changes linked to schizophrenia, finding region-specific gene dysregulation and synaptic protein alterations.

bioRxiv · Nov 15, 2024 · PreprintNeuroscience

Deep proteomics identifies shared molecular pathway alterations in synapses of schizophrenia and bipolar disorder patients and mouse model

Sameer Aryal, Kevin Bonanno, Bryan J. Song, D.R. Mani, Hasmik Keshishian, Steven A. Carr, Morgan Sheng, Borislav Dejanovic

Cell Reports · May 1, 2023Peer-reviewedNeuroscience

Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

Zohreh Farsi, Ally A. Nicolella, Sean Simmons, Sameer Aryal, Nate Shepard, Kira S. Brenner, Sherry Lin, Linnea E. Herzog, Wangyong Shin, Vahid Gazestani, Bryan J. Song, Kevin Bonanno, Hasmik Keshishian, Steven A. Carr, Evan Z. Macosko, , Morgan Sheng

This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.

bioRxiv · Nov 15, 2022 · PreprintNeuroscience