Silvia Onesti

Charting the Structure and Functional Landscape of the SF3B1 Intrinsically Disordered Region

This study characterizes the conformational dynamics and phosphorylation-dependent changes in the SF3B1 N-terminal domain using a combination of biophysical and computational methods.

Albumin-coated VS1 nanocrystals enable STARD3 inhibition and potentiate fluoropyrimidine therapy in colorectal cancer

This paper develops albumin-coated nanocrystals to improve the solubility and delivery of the STARD3 inhibitor VS1, enhancing its synergistic effect with 5-FU in colorectal cancer.

FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability

This study identifies FANCJ's interaction with AND-1 as critical for replisome recruitment and genome stability, showing that mutations in the CIP box impair this function and contribute to cancer risk.