Minji Ai

Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in Systemic Lupus Erythematosus

This study investigates the role of mTORC2 in SLE and shows that targeting mTORC2 reduces immunopathology in both mouse models and human PBMCs.

PP2A catalytic subunit alpha is critically required for CD8+ T cell homeostasis and anti-bacterial responses

This study shows that PP2A catalytic subunit alpha is essential for CD8+ T cell homeostasis and anti-bacterial responses, with Bcl2 rescue limited to spleen.

Human mesenchymal stem cells and derived extracellular vesicles reduce sensory neuron hyperexcitability and pain-related behaviors in a mouse model of osteoarthritis

Functional characterization of ovine dorsal root ganglion neurons reveals peripheral sensitization after osteochondral defect

This study shows that ovine dorsal root ganglion neurons from osteochondral defect models exhibit increased excitability and TRPV1 function, indicating peripheral sensitization.