Author

Pablo Castro‐Hartmann

Materials and Structural Analysis, Thermo Fisher Scientific, 5651 GG Eindhoven, Netherlands;ORCID 0000-0002-8991-9560Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Pu QianiD· 2 shared Amanda A BrindleyiD· 1 shared Anastasiia GusachiD· 1 shared Andrew HitchcockiD· 1 shared C Neil HunteriD· 1 shared Christopher G. TateiD· 1 shared Christopher J. RussoiD· 1 shared Dari KimaniusiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Pu QianORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cryo-EM structures of Cereibacter sphaeroides ferrochelatase reveal an oligomeric state that occludes the substrate-binding site

Jack H Salisbury, Pu Qian, Yibo Jin, Amanda A Brindley, Joshua R Barrett, Nathan B P Adams, Ruby R E Harvey, Frederick R Hawkings, Harold A Cannon, George A Sutherland, Matthew P Johnson, James D Reid, David J K Swainsbury, Pablo Castro-Hartmann, Per A Bullough, , Andrew Hitchcock

This study determines the cryo-EM structures of Cereibacter sphaeroides ferrochelatase, revealing oligomeric states that occlude the substrate-binding site.

bioRxiv · Nov 3, 2026 · PreprintBiochemistry

Insights from aquaporin structures into drug-resistant sleeping sickness

Modestas Matusevicius, Robin Adam Corey, Marcos Gragera, Keitaro Yamashita, Teresa Sprenger, Marzuq A. Ungogo, James N. Blaza, Pablo Castro‐Hartmann, Dimitri Y. Chirgadze, Sundeep Chaitanya Vedithi, Pavel Afanasyev, Roberto Melero, Rangana Warshamanage, Anastasiia Gusach, J.M. Carazo, , Simone N. Weyand

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

eLife · Dec 31, 2025Peer-reviewedMolecular Biology

Structural basis for the inhibition of the SARS-CoV-2 RNA-dependent RNA polymerase by favipiravir-RTP

Katerina Naydenova, Kyle Muir, Long-Fei Wu, Ziguo Zhang, Francesca Coscia, Mathew James Peet, Pablo Castro‐Hartmann, Qian Pu, Kasim Sader, Kyle C. Dent, Dari Kimanius, John D. Sutherland, Jan Löwe, David Barford, Christopher J. Russo

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.

bioRxiv · Oct 21, 2020 · PreprintMolecular Biology