Ziguo Zhang

This study uses cryo-EM to reveal structural mechanisms of KMN complex assembly and phospho-regulation in budding yeast kinetochores.

The paper determines cryo-EM structures of the CCAN complex bound to different DNA sequences to understand its architecture on centromeric α-satellite CENP-A nucleosome arrays.

This study elucidates how the Cdc20MIM induces Mad2 conformational conversion by transiently exposing a binding site and facilitating structural changes.

This study compares cryo-EM structures of S. cerevisiae and human APC/C complexes, revealing conserved architectures and differences in regulatory mechanisms.

The paper describes the structure of the budding yeast outer kinetochore complexes and how phosphorylation regulates their stability during mitotic error correction.

This study determines the structure of favipiravir-RTP bound to SARS-CoV-2 RdRp, revealing its weak incorporation mechanism and low replication suppression.