Douglas G. McMahon

Photoperiodic Regulation of SK Channels in Dorsal Raphe Serotonin Neurons

This study shows that photoperiod modulates SK channel function in dorsal raphe serotonin neurons through post-transcriptional mechanisms, linking seasonal cues to mood-related behaviors.

Gene expression plasticity of the mammalian brain circadian clock in response to photoperiod

The paper investigates how photoperiod affects SCN gene expression in mice, identifying key genes and pathways involved in circadian plasticity.

DNA methylation is a widespread mechanism of light-induced circadian clock period plasticity

The paper shows DNA methylation in the SCN mediates light-induced circadian period after-effects, both from photoperiod changes and single light pulses.

Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

Light sets the brain's daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk

The paper shows light adjusts the brain's circadian clock by altering molecular clockwaveforms in specific SCN regions to simulate dawn and dusk, enabling seasonal timekeeping.

Optogenetic stimulation of VIPergic SCN neurons induces photoperiodic changes in the mammalian circadian clock

The paper shows that optogenetic activation of VIPergic SCN neurons mimics the effects of extended photoperiod on circadian rhythms and behavior.

Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons

This study shows that photoperiod affects TREK-1 channel function and expression in dorsal raphe serotonergic neurons, influencing their excitability.

Photoperiodic Effects on Monoamine Signaling & Gene Expression Throughout Development in the Serotonin & Dopamine Systems

This study examines how different photoperiods affect gene expression and monoamine levels in the dopamine and serotonin systems across mouse development.

Distinct components of photoperiodic light are differentially encoded by the mammalian circadian clock

The paper investigates how different components of photoperiodic light influence circadian clock properties through behavioral and SCN measurements.