Pat R. Levitt

Early Life Adversity Produces Enduring Molecular and Functional Disruption of Developing Vagal Circuits

This study shows that early life adversity disrupts vagal circuit development in mice, with sex-specific changes in mitochondrial function and autonomic stress responses.

Photoperiodic Regulation of SK Channels in Dorsal Raphe Serotonin Neurons

This study shows that photoperiod modulates SK channel function in dorsal raphe serotonin neurons through post-transcriptional mechanisms, linking seasonal cues to mood-related behaviors.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Mouse Brain Extractor: Brain segmentation of mouse MRI using global positional encoding and SwinUNETR

The paper develops a deep learning method for mouse MRI brain segmentation using global positional encoding, achieving high accuracy and outperforming existing methods.

Developmental and molecular contributions to contextual fear memory emergence in mice

This study examines the developmental emergence of contextual fear memory in mice, showing a rapid transition from P20 to P21 and delayed deficits in young adulthood linked to MET receptor expression.

Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency

The paper shows that incorporating genetic diversity into mouse models of neurodevelopmental disorders recapitulates human genetic and symptom heterogeneity associated with CHD8 haploinsufficiency.

SCAMPR: Single-Cell Automated Multiplex Pipeline for RNA Quantification and Spatial Mapping

SCAMPR is a pipeline for quantifying and spatially mapping mRNA expression in neurons, demonstrating its effectiveness in analyzing gene expression changes due to early life stress.

Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons

This study shows that photoperiod affects TREK-1 channel function and expression in dorsal raphe serotonergic neurons, influencing their excitability.

Photoperiodic Effects on Monoamine Signaling & Gene Expression Throughout Development in the Serotonin & Dopamine Systems

This study examines how different photoperiods affect gene expression and monoamine levels in the dopamine and serotonin systems across mouse development.

Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults

This study identifies age- and sex-specific mitochondrial and proteomic adaptations in the hippocampus and liver following early-life stress in mice.

MET Receptor Tyrosine Kinase Regulates Vagal Laryngeal Motor Neuron Development and Lifespan Ultrasonic Vocal Communication

This study shows that MET receptor tyrosine kinase is essential for the development of laryngeal motor neurons and their function in ultrasonic vocalization in mice.

FOXP2 exhibits neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

The paper examines FOXP2 expression and function in mouse cortical development, finding that its removal does not disrupt many previously proposed developmental processes.