Sarah E. Ryan

LIF is a pro-algesic mediator in human and mouse models of arthritis-related pain

This study identifies LIF as a key pro-algesic cytokine in arthritis-related pain, showing its role in neuronal signalling and pain-like behaviours in human and mouse models.

Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritis

The paper identifies shared CD8+ T-cell clones between skin and joint in psoriatic arthritis, suggesting clonal migration and coordinated inflammation.

Blockade of rheumatoid arthritis synovial fluid-induced sensory neuron activation by JAK inhibitors

This study shows JAK inhibitors block RA synovial fluid-induced sensory neuron activation by inhibiting STAT3 phosphorylation and pain gene expression.

Lipidome profiling of neutrophil-derived extracellular vesicles unveils their contribution to the ensemble of synovial fluid-derived extracellular vesicles during joint inflammation

The paper profiles lipidomes of neutrophil-derived extracellular vesicles in joint inflammation and finds species-specific lipid changes linked to inflammatory conditions.