Stefan A. Berghoff

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

Peripheral AAV-mediated delivery of brain-penetrant PGRN rescues TDP-43 pathology, neurodegeneration and motor phenotypes in FTLD-GRN models.

This study correlates spatial transcriptomics with electron microscopy to link microglial morphology with transcriptional signatures in mouse brain.

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

The paper shows that neuronal cholesterol synthesis is critical for remyelination in chronic demyelination models and MS patients.