Meng Zhao

Python metabolomics uncovers a conserved postprandial metabolite and gut-brain feeding pathway

The paper identifies a conserved postprandial metabolite, pTOS, that links nutrient intake to energy balance through a gut-brain pathway in pythons and mice, with potential relevance to humans.

15-PGDH Inhibition Overcomes Muscle Regenerative Deficit Seen With GLP1-Receptor Agonist-Induced Weight Loss

The paper shows that inhibiting 15-PGDH counteracts muscle regeneration deficits caused by GLP-1 receptor agonist-induced weight loss in mice.

A secondary β-hydroxybutyrate metabolic pathway linked to energy balance

This study identifies a secondary BHB metabolic pathway mediated by CNDP2, leading to BHB-amino acid metabolites that regulate energy balance in mice and humans.

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

Loss of RREB1 reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes

This study shows that reducing RREB1 in mice and humans decreases adipogenesis and improves insulin sensitivity, linking RREB1 to type 2 diabetes risk.

Organism-wide secretome mapping uncovers pathways of tissue crosstalk in exercise

This study maps the organism-wide secretome response to exercise in mice, identifying 200+ exercise-regulated protein pairs and uncovering anti-obesity and anti-diabetic roles of a liver-secreted proteoform.