Author

Mandy S. M. Wan

Institute of Cancer ResearchORCID 0000-0002-0679-4142Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Claudio AlfieriiD· 2 shared Jyoti Sharma ChoudharyiD· 2 shared Chiara MarcozziiD· 1 shared Fernando J. SialanaiD· 1 shared Fuzhou YeiD· 1 shared Jessica A. DownsiD· 1 shared Karen A. LaneiD· 1 shared Liudmila Shcherbakova· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiochemistry

Claudio AlfieriORCID

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2 papers

Recent·Most cited

High resolution interaction surface mapping by PRISMA reveals novel ARID1A interactions

Mercedes Pardo, Chiara Marcozzi, Karen A. Lane, Fernando J. Sialana, Liudmila Shcherbakova, Zuza Kozik, Mandy S. M. Wan, Fuzhou Ye, Claudio Alfieri, Jessica A. Downs, Jyoti Sharma Choudhary

This study uses PRISMA to identify and map novel ARID1A interactions at high sequence resolution, revealing new interactors and a regulatory mechanism involving CDK2 phosphorylation.

bioRxiv · Mar 18, 2026 · PreprintBiochemistry

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex

Mandy S. M. Wan, Reyhan Muhammad, Marios G. Koliopoulos, Theodoros I. Roumeliotis, Jyoti Sharma Choudhary, Claudio Alfieri

The paper presents the structure of the SIN3B histone deacetylase complex and elucidates its mechanism of substrate recognition and catalysis.

Nature Communications · May 3, 2023Peer-reviewedMolecular Biology