Author

Lucas Moreno

Hospital Infantil Universitario Niño JesúsORCID 0000-0002-0708-1670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alvin Farrell· 1 shared Amelie S. WenziD· 1 shared Andrew D.J. PearsoniD· 1 shared Andrew S. MooreiD· 1 shared Aroa SorianoiD· 1 shared Brian A. WalkeriD· 1 shared Caedyn L. StinsoniD· 1 shared Chris JonesiD· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperGenomics

Alvin Farrell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Combined inhibition of MDM2 and PARP lead to a synergistic anti-tumoral response in p53 wild-type rhabdomyosarcoma models

Guillem Pons, Patricia Zarzosa, Gabriel Gallo-Oller, Amelie S. Wenz, Maris Lapins, Lia García-Gilabert, Júlia Sansa-Girona, Natalia Navarro, Miguel F. Segura, Aroa Soriano, Gabriela Guillén, Raquel Hladun, Josep Sánchez de Toledo, Soledad Gallego, Jordi Carreras Puigvert, , Josep M Roma

This study shows that combining MDM2 and PARP inhibitors synergistically inhibits p53 wild-type rhabdomyosarcoma growth in vitro and in vivo.

bioRxiv · Dec 3, 2024 · PreprintCancer Biology

BPTF cooperates with MYCN and MYC to link neuroblastoma cell cycle control to epigenetic cellular states

Irene Felipe‐Abrio, Jaime Martínez-de-Villarreal, Khushbu Patel, Jorge Luis Martinez-Torrecuadrada, Liron D. Grossmann, Giovanna Roncador, Mariona Cubells, Alvin Farrell, Nathan M. Kendsersky, Sergio Sabroso‐Lasa, Lucía Sancho-Temiño, Kyabeth Torres-Rodriguez, Daniel Martínez, Javier Muñoz Perez, Fernando García, , Francisco X. Real

This study shows BPTF works with MYCN and MYC to control cell cycle and epigenetic states in neuroblastoma, linking it to poor prognosis and therapeutic potential.

bioRxiv · Feb 11, 2024 · PreprintGenomics

Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours

Elisa Izquierdo, Lina Yuan, Sally L. George, Michael J.F. Hubank, Chris Jones, Paula Proszek, JANET M. SHIPLEY, Susanne A. Gatz, Caedyn L. Stinson, Andrew S. Moore, Steven C. Clifford, Debbie Hicks, Janet C. Lindsey, Rebecca M. Hill, Thomas S. Jacques, , David González de Castro

The paper develops a targeted sequencing panel for paediatric solid tumours and validates its sensitivity and specificity across various sample types.

Oncotarget · Dec 6, 2017Peer-reviewedGenomics