Author

Mary Tenuta

Rockefeller UniversityORCID 0000-0002-0708-3932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrew J. MacLeaniD· 1 shared Andriy GoychukiD· 1 shared Anna GazumyaniD· 1 shared Arup K. ChakrabortyiD· 1 shared Brianna HernandeziD· 1 shared Clara UheiD· 1 shared Dennis J. Schaefer-BabajewiD· 1 shared Gabriela S Silva Santos· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Andrew J. MacLeanORCID

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1 paper

Recent·Most cited

Biophysical properties of IgD determine thresholds for self-tolerance and selection into germinal centers

Lachlan Paul Deimel, Ryan A. Brady, Andriy Goychuk, Gabriela S Silva Santos, Clara Uhe, Andrew J. MacLean, Brianna Hernandez, Shuai Zong, Laurine Binet, Mary Tenuta, Dennis J. Schaefer-Babajew, Zeliha Kilic, Anna Gazumyan, Thiago Y. Oliveira, Harald Hartweger, , Michel C. Nussenzweig

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

bioRxiv · Jul 7, 2026 · PreprintImmunology