Andrew J. MacLean

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

The paper shows that late-entering B cells in germinal centers mainly become memory B cells that recognize less common antigen parts.

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

The paper shows that high-affinity B cells divide more and receive more Tfh help, leading to affinity maturation in plasma cells.