Harald Hartweger

This study shows that B cells support tumor-specific CD4 T cells to enhance PD-1 blockade efficacy, but antibody secretion is not necessary for long-term survival.

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

This study uses TRACK mice to show tissue-specific clonal selection and differentiation of CD4+ T cells during influenza infection, revealing organ-specific transcriptional programs and memory formation patterns.

The paper shows that late-entering B cells in germinal centers mainly become memory B cells that recognize less common antigen parts.

This paper develops a method to generate TCR knock-in mice with functional T cells by integrating TCRβ sequences into the Trb locus using AAV and CRISPR/Cas9, overcoming limitations of traditional transgenic models.

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

This paper designs and tests an HIV-1 vaccine candidate that targets three bNAb epitopes, showing it elicits combined immune responses in animal models.