Lachlan Paul Deimel

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

The paper shows that high-affinity B cells divide more and receive more Tfh help, leading to affinity maturation in plasma cells.