Anna Gazumyan

Biophysical properties of IgD determine thresholds for self-tolerance and selection into germinal centers

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

Antibody Mediated Diversification of Primary and Secondary Humoral Immune Responses

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.

Fc receptor dependent and independent mechanisms of antibody-mediatedenhancement of immune responses

This study identifies Fc gamma receptor-dependent and independent mechanisms by which pre-existing antibodies enhance germinal center and plasmablast responses and alter the affinity threshold for B cell recruitment.

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes

The paper shows that late-entering B cells in germinal centers mainly become memory B cells that recognize less common antigen parts.

Memory B cell Development in Response to mRNA SARS-CoV-2 and Nanoparticle Immunization in Mice

This study compares memory B cell responses to mRNA and nanoparticle vaccines in mice, finding similar antibody sequences but better breadth from mosaic nanoparticle vaccines.

Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

Affinity maturation of antibody responses is mediated by differential plasma cell proliferation

The paper shows that high-affinity B cells divide more and receive more Tfh help, leading to affinity maturation in plasma cells.