Dennis J. Schaefer-Babajew

Antibody-mediated antigen tethering as a regulator of germinal-center B cell affinity and diversity

This study shows that antibody-mediated antigen tethering helps balance affinity and diversity in germinal center B cells by improving robustness during affinity maturation.

Biophysical properties of IgD determine thresholds for self-tolerance and selection into germinal centers

This study shows that IgD's long hinge increases entropic cost in antigen binding, reducing negative selection and raising the threshold for germinal center entry.

Antibody Mediated Diversification of Primary and Secondary Humoral Immune Responses

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.