Laura Pereira

Tunable Expression of an AAV Payload Using ADAR-mediated RNA Editing

This paper demonstrates an ADAR-mediated gene switch to control AAV-delivered gene expression by rescuing a premature termination codon via RNA editing, achieving tunable and clinically relevant therapeutic protein levels.

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox

The paper develops a CRISPR/Cas13d-based method to specifically knockdown RNA isoforms and provides computational tools for experimental design and analysis.

Timing mechanism of sexually dimorphic nervous system differentiation

The paper identifies a regulatory pathway controlling the timing of sexual differentiation in C. elegans and shows its conservation in mice and humans.

Dopamine Negatively Modulates the NCA Ion Channels in C. elegans

This study identifies a pathway by which dopamine modulates NCA channel activity in C. elegans through Gq-Rho and GRK-2 signaling.