Bjarne Klopprogge

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.

Engineering orthogonal ribosomes for real-time monitoring using fluorescence

This paper engineers fluorescent orthogonal ribosomes to monitor synthetic protein production in bacteria, identifying an insertion site that enhances ribosome activity and enables dynamic tracking.

Tailored synthetic sRNAs dynamically tune multilayer genetic circuits

The paper designs synthetic sRNAs to dynamically modulate gene expression in E. coli without altering existing genetic circuits.