Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration
Dibyadeep Datta, Isabella Perone, Denethi Wijegunawardana, Feng Liang, Yury M. Morozov, Jon I. Arellano, Alvaro Duque, Zhongcong Xie, Christopher H. van Dyck, Mary Kate P. Joyce, Amy F.T. Arnsten
The paper examines pT217-tau localization in aged rhesus macaques, showing its aggregation on microtubules and trafficking between neurons, supporting its role as a fluid biomarker for early neurodegeneration.
Alzheimer s & Dementia · Mar 6, 2024Peer-reviewedNeuroscience