Author

Isabella Perone

Yale UniversityORCID 0000-0002-9831-7342Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:non-human primate· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Alvaro DuqueiD· 2 shared Amy F.T. ArnsteniD· 2 shared Dibyadeep DattaiD· 2 shared Jon I. ArellanoiD· 2 shared Caroline Jutta Zeiss· 1 shared Christopher H. van DyckiD· 1 shared Denethi WijegunawardanaiD· 1 shared Dinara Bolat· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Alvaro DuqueORCID

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2 papers

Recent·Most cited

Loss of calbindin and rise in pT217-tau in aging monkey prefrontal cortical dendrites

Isabella Perone, Dinara Bolat, Zhiling Gu, Caroline Jutta Zeiss, Eliza Bliss‐Moreau, Alvaro Duque, Jon I. Arellano, Yize Zhao, Dibyadeep Datta, Amy F.T. Arnsten

The paper shows that aging macaques lose calbindin and gain pT217-tau in prefrontal cortical dendrites, linking calbindin loss to increased tau pathology and AD risk.

bioRxiv · Aug 23, 2026 · PreprintNeuroscience

Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration

Dibyadeep Datta, Isabella Perone, Denethi Wijegunawardana, Feng Liang, Yury M. Morozov, Jon I. Arellano, Alvaro Duque, Zhongcong Xie, Christopher H. van Dyck, Mary Kate P. Joyce, Amy F.T. Arnsten

The paper examines pT217-tau localization in aged rhesus macaques, showing its aggregation on microtubules and trafficking between neurons, supporting its role as a fluid biomarker for early neurodegeneration.

Alzheimer s & Dementia · Mar 6, 2024Peer-reviewedNeuroscience