Alvaro Duque

The paper shows that aging macaques lose calbindin and gain pT217-tau in prefrontal cortical dendrites, linking calbindin loss to increased tau pathology and AD risk.

The paper presents the MIND model, showing that competing induction and exclusion programs shape the sensorimotor-to-association axis in the neocortex across species.

The paper identifies human-specific transcriptomic and regulatory features in the cerebellum, including ZP2's role in synapse development and regulation.

The temporal analysis of gene regulatory networks in human neural stem cells reveals multiple early critical phases associated with cortical disorders and neuropsychiatric traits.

The paper compares distractibility between marmosets and macaques in cognitive tasks and links it to dopamine D1 receptor expression in prefrontal parvalbumin neurons.

This study identifies age-related calcium signaling dysregulation in macaque entorhinal cortex linked to early tau hyperphosphorylation, suggesting a mechanism for Alzheimer's disease initiation.

This study compares extrasynaptic and synaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices using immunoelectron microscopy, finding higher extrasynaptic expression in subgenual cortex and higher synaptic expression in dorsolateral prefrontal cortex.

The paper identifies a conserved cellular-to-spectral rule in primate cortex that predicts the spectrolaminar motif across brain areas and validates it in schizophrenia post-mortem data.

The paper examines pT217-tau localization in aged rhesus macaques, showing its aggregation on microtubules and trafficking between neurons, supporting its role as a fluid biomarker for early neurodegeneration.

The paper uses single-cell transcriptomics to identify molecular programs in developing macaque telencephalon, revealing primate-specific signaling and gene roles in regional specification and neural stem cell fate.

This study investigates the origin and development of the claustrum in rhesus macaques, identifying its independent formation and molecular characteristics.