Jon I. Arellano

Loss of calbindin and rise in pT217-tau in aging monkey prefrontal cortical dendrites

The paper shows that aging macaques lose calbindin and gain pT217-tau in prefrontal cortical dendrites, linking calbindin loss to increased tau pathology and AD risk.

An update on the model of connectivity of the hippocampal formation (I): the perforant pathway to the dentate gyrus

The paper updates a model of connectivity from the entorhinal cortex to the dentate gyrus, revealing higher divergence and synaptic complexity than previously described.

Updated neuronal numbers of the rat hippocampal formation: redesigning the hippocampal model.

The paper updates neuronal counts in the rat hippocampal formation by aggregating data from 89 studies, revealing significant differences from traditional estimates.

Dopamine D1 receptor expression in prefrontal parvalbumin neurons influences distractibility across species

The paper compares distractibility between marmosets and macaques in cognitive tasks and links it to dopamine D1 receptor expression in prefrontal parvalbumin neurons.

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.

This study identifies age-related calcium signaling dysregulation in macaque entorhinal cortex linked to early tau hyperphosphorylation, suggesting a mechanism for Alzheimer's disease initiation.

Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices

This study compares extrasynaptic and synaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices using immunoelectron microscopy, finding higher extrasynaptic expression in subgenual cortex and higher synaptic expression in dorsolateral prefrontal cortex.

Meta-analysis: a quantitative model of adult neurogenesis in the rodent hippocampus

This paper quantitatively models the decline of adult neurogenesis in rodents across age, showing a significant reduction in new neurons' proportion in the hippocampus.

Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration

The paper examines pT217-tau localization in aged rhesus macaques, showing its aggregation on microtubules and trafficking between neurons, supporting its role as a fluid biomarker for early neurodegeneration.

Molecular programs of regional specification and neural stem cell fate progression in developing macaque telencephalon

The paper uses single-cell transcriptomics to identify molecular programs in developing macaque telencephalon, revealing primate-specific signaling and gene roles in regional specification and neural stem cell fate.

Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates

The paper models the progression of human neural stem cells in vitro, showing they transition through organizer states before committing to cortical excitatory or inhibitory neuronal fates.

Molecular Diversity Among Adult Hippocampal and Entorhinal Cells

The paper identifies molecular diversity in adult hippocampal and entorhinal cells, revealing cell-type-specific properties related to Alzheimer's disease vulnerability.