Author

Huan Chen

Guangzhou Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

Click to filter author papers

Developmental Biology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Baomei Cai· 2 shared Duanqing PeiiD· 2 shared Jiekai CheniD· 2 shared Shangtao CaoiD· 2 shared Bing XuiD· 1 shared Binlin DaiD· 1 shared Chunhua Zhou· 1 shared Dajiang QiniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersDevelopmental Biology

Baomei Cai

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SP2 impedes the pluripotent-to-totipotent state transition in an RA-dependent manner

Hu S, Pinghui Zhu, Liu H, Huan Chen, Shunlan Xu, 郭恩静, Baomei Cai, Xiongzhi Quan, Duanqing Pei, J S Chen, H B Wu, Shangtao Cao

This study identifies SP2 as a barrier to the pluripotency-to-totipotency transition in mouse embryonic stem cells, showing its role in promoting alternative developmental programs.

bioRxiv · Oct 12, 2026 · PreprintDevelopmental Biology

A Single-Cell Temporal Atlas of Mouse Nasal Embryonic Development

Huan Chen, Yuehua Chen, Mengjie Pan, Ziyu Feng, Baomei Cai, Yiyi Cheng, Sihao Chen, Jiehong Deng, Xia Yao, Chunhua Zhou, Yunjing Du, Wei He, Ruifang Zhang, Yudong Fu, Shujuan Liu, , Shangtao Cao

This study creates a single-cell RNA sequencing atlas of mouse nasal development, identifying cell clusters and subtypes, and revealing regulators of lineage specification.

bioRxiv · Apr 16, 2026 · PreprintDevelopmental Biology

SIRT4 enhances the cytotoxicity of NK cells toward hepatic stellate cells and reverses liver fibrosis via AMPKα/P-p53/NKG2DL pathway

Huan Chen, Binlin Da, Zihao Cai, Rui Fang, Xiaolin Xie, Han Zhang, Si Zhao, Ming Zhang, Lei Wang, Bing Xu, Yuzheng Zhuge, Feng Zhang

This study shows SIRT4 enhances NK cell cytotoxicity against HSCs and reverses liver fibrosis via the AMPKα/P-p53/NKG2DL pathway using AAV-mediated delivery.

bioRxiv · Sep 30, 2024 · PreprintCell Biology

Clostridium ablates tumors by degrading collagen mesh andinducing ferroptosis

Fengmin Yang, Lu Meng, Huan Chen, Xinyue Wang, Mengmeng Zhang, Zhenping Cao, Yan Pang, Jinyao Liu

This paper describes a Clostridium strain that degrades collagen and induces ferroptosis in tumors, leading to effective tumor destruction in mice.

bioRxiv · May 15, 2024 · PreprintMicrobiology