Author

Jonas Goßen

Forschungszentrum JülichORCID 0000-0002-0730-6796Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Giulia RossettiiD· 4 shared Alejandro GiorgettiiD· 2 shared Rui Pedro RibeiroiD· 2 shared Andrea R. BeccariiD· 1 shared Andrea ZalianiiD· 1 shared Angela CoronaiD· 1 shared Barbara GiabbaiiD· 1 shared Bernd NeumaieriD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBioinformatics

Giulia RossettiORCID

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4 papers

Recent·Most cited

KIRA6 is an effective and versatile mast cell inhibitor of IgE-mediated activation

Veronika Wunderle, Thomas Wilhelm, Shatha Boukeileh, Jonas Goßen, Michael A. Margreiter, Roman Sakurov, Sandro Capellmann, Maike Schwoerer, Nabil Ahmed, Gina Bronneberg, Michel Arock, Christian Martin, Thomas E. O. Schubert, Francesca Levi‐Schaffer, Giulia Rossetti, , Michael Huber

This study identifies KIRA6 as a dual inhibitor of LYN and FYN that suppresses IgE-mediated mast cell activation and inflammation.

European Journal of Immunology · Dec 15, 2024Peer-reviewedImmunology

AI-based novel-chemotype GPCRs drugs: introducing ligand type classifiers and systems biology

Jonas Goßen, Rui Pedro Ribeiro, Dirk DB Bier, Bernd Neumaier, Paolo Carloni, Alejandro Giorgetti, Giulia Rossetti

The paper presents an AI-based method to identify novel chemotype ligands for GPCRs by combining structural data, a random forest classifier, and a kinetic model, demonstrating its effectiveness with a new antagonist for the adenosine A2A receptor.

bioRxiv · Mar 31, 2023 · PreprintBioinformatics

SSB toolkit: from molecular structure to subcellular signaling pathways.

Rui Pedro Ribeiro, Jonas Goßen, Giulia Rossetti, Alejandro Giorgetti

The paper introduces an open-source systems biology toolkit to simulate GPCR signal-transduction pathways using structural data and mathematical models.

bioRxiv · Nov 8, 2022 · PreprintBioinformatics

Identification of inhibitors of SARS-CoV-2 3CL-Pro enzymatic activity using a small molecule in-vitro repurposing screen

Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geißlinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, , Andrea Zaliani

The paper identifies 62 new inhibitors of SARS-CoV-2 3CL-Pro through a compound repurposing screen and validates their activity using X-ray crystallography.

ACS Pharmacology & Translational Science · Mar 11, 2021Peer-reviewedMolecular Biology