Author

Cindy J. Castelle

ORCID 0000-0002-0751-9804Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Cindy J. Castelle1 paper

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Christopher T. BrowniD· 2 shared Cristina N. ButterfieldiD· 2 shared Daniela S. Aliaga GoltsmaniD· 2 shared David Ward TayloriD· 2 shared Isabella Krudop· 2 shared Liliana Gonzalez‐Osorio· 2 shared Lisa M. AlexanderiD· 2 shared Nicole C. ThomasiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Christopher T. BrownORCID

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2 papers

Recent·Most cited

Compact adenine base editors to enable therapeutic rescue of Duchenne muscular dystrophy

Kartik Lakshmi Rallapalli, Joanne M. L. Ho, Isabel Nocedal, Jin Wen Tan, Rodrigo Fregoso Ocampo, Nicole C. Thomas, Brandon Justice, Samatar Jirde, Liliana Gonzalez‐Osorio, Cindy J. Castelle, Jyun‐Liang Lin, Jacquelyn T. Wright, Soungsothira Toch, Krushangi Shah, Benjamin Freeman, , Cristina N. Butterfield

This paper develops compact adenine base editors for in vivo gene editing, demonstrating their application in Duchenne muscular dystrophy by enabling exon skipping through targeted splice-site disruption.

bioRxiv · May 12, 2026 · PreprintBioengineering

Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency

Kaoling Guan, Rodrigo Fregoso Ocampo, Paula B. Matheus Carnevali, Cindy J. Castelle, Liliana Gonzalez‐Osorio, Dominic T. Castanzo, Nicole C. Thomas, Molly Brothers, Tyler L. Dangerfield, Matthew M. Hooper, Madeline S. West, Nathan M. Appleby, Isabella Krudop, Rebecca C. Lamothe, Daniela S. Aliaga Goltsman, , David Ward Taylor

The paper compares Cas12f orthologs to identify mechanistic features that enhance genome editing efficiency in human cells.

Nature Structural & Molecular Biology · Apr 13, 2026Peer-reviewedBiochemistry