Variation at the R181 residue of p53 confers loss of p53 DNA binding cooperativity with the retention of mitochondrial-associated apoptosis
Renyta Moses, Alexandra Indeglia, Alison Schwartz Levine, Ryan M. Hausler, Gregory Kelly, Sven A. Miller, Isabel Anez-Bruzual, Melissa Heller, R Delgado, Caitlin Orr, Wendy Kohlmann, Anne Naumer, Jennie Vagher, Sophie R Cahill, Luke Devon Maese, , Kara N. Maxwell
This study shows that p53 variants with R181 mutations retain mitochondrial apoptosis function but lose DNA binding cooperativity, leading to reduced cancer risk.
Molecular Cancer Research · May 18, 2026Peer-reviewedCancer Biology