Author

David J. Marcus

University of WashingtonORCID 0000-0002-0767-4249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Approach:machine learning (classical)· 2 Assay:behavioral assay· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Michael R. BruchasiD· 5 shared Benjamin Bruce LandiD· 3 shared Larry S. ZweifeliD· 2 shared Nephi StellaiD· 2 shared Sean C. PiantadosiiD· 2 shared Abigail J. Elerding· 1 shared Adam Gordon-FennelliD· 1 shared Allan Levy· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersNeuroscience

Michael R. BruchasORCID

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Author profile →

5 papers

Recent·Most cited

Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area.

Carrie Stine, Amanda Loren Pasqualini, Ananya S. Achanta, Joseph C. Johnson, Sanjana Jadhav, David J. Marcus, Michael R. Bruchas

The paper identifies a stress-sensitive N/OFQ-containing neuronal population in the pnVTA and characterizes its functional inputs from the lateral hypothalamus.

Neuropsychopharmacology · Dec 20, 2025Peer-reviewedNeuroscience

Behavioral Decoding Reveals Cortical Endocannabinoid Potentiation during Δ9-THC Impairment

Anthony English, David J. Marcus, Khushi Yadav, Yassin Elkhouly, Allan Levy, Victoria L. Corbit, M. Ask, Anika Scedberg, Jordan Poces-Ball, Fleur Uittenbogaard, Rayna Simons, Ilana B. Witten, Larry S. Zweifel, Benjamin Bruce Land, Nephi Stella, Michael R. Bruchas

The paper investigates how THC impairs mouse behavior by altering mPFC excitatory/inhibitory balance through endocannabinoid release.

bioRxiv · Sep 26, 2025 · PreprintNeuroscience

Endocannabinoids facilitate transitory reward engagement through retrograde gain control

David J. Marcus, Anthony E. English, Gunn Chun, Emmaline F. Seth, Rachel Oomen, Sabrina Hwang, Bailey A Wells, Sean C. Piantadosi, Azra Vajzovic Suko, Yulong Li, Larry S. Zweifel, Benjamin Bruce Land, Nephi Stella, Michael R. Bruchas

This study investigates the role of endocannabinoids in reward-seeking behavior through thalamo-striatal circuits using in vivo and machine learning methods.

bioRxiv · Jan 6, 2025 · PreprintNeuroscience

Insular opioid signaling and distinct claustral ensembles in hedonic feeding

Jingyi Chen, Leandra R. Mangieri, Sophia Mar, Sean C. Piantadosi, David J. Marcus, Phoenix Davis, Benjamin Bruce Land, Michael R. Bruchas

This study identifies an insular-claustral opioid circuit that stress modulates to influence hedonic feeding through KOR signaling and prodynorphin-expressing neurons.

bioRxiv · Jun 10, 2024 · PreprintNeuroscience

Endogenous opioid dynamics in the dorsal striatum sculpt neural activity to control goal-directed action

Raajaram Gowrishankar, Madelyn M. Hjort, Abigail J. Elerding, Sofia E. Shirley, Josie Van Tilburg, David J. Marcus, Pranav Senthilkumar, Khalid Abrera, Dustin Sumarli, Katherine Motovilov, Valerie Lau, Adam Gordon-Fennell, Zhe Charles Zhou, Chunyang Dong, Lin Tian, , Michael R. Bruchas

This study identifies the role of endogenous dynorphin release in the dorsal striatum in regulating goal-directed behavior through retrograde GPCR inhibition.

bioRxiv · May 20, 2024 · PreprintNeuroscience