Yasaman Kargar Gaz Kooh

This study uses tunable magnetorheological elastomer substrates to investigate mechano-genetic interactions in HCM by applying dynamic mechanical stress to hiPSC-derived cardiomyocytes with a MYBPC3 mutation.

This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.

This study develops a xeno-free hydrogel platform to support hiPSC expansion and in situ differentiation into structurally mature cardiomyocytes.

This paper develops a micro-engineered heart tissue model of desmin-related cardiomyopathy caused by mutant αB crystallin, showing aggregation, contractile dysfunction, and potential therapeutic response to JAK1 inhibition.