Lindsey A. Chew

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

This study shows that AAV-delivered truncated CFH gene therapy can reverse C3G in mice and suggests its potential for treating AMD.

This study shows that cone-mediated signaling remains robust in retinal ganglion cells despite rod photoreceptor degeneration, suggesting gene therapies may still effectively preserve vision.

This study shows that preventing CRMP2 SUMOylation reduces mechanical allodynia in female neuropathic pain models but not in males or other pain types.

The paper identifies a novel CaV2.2 channel antagonist with broad antinociceptive effects and reduced side effects in pain models.