Mishek Thapa

This study compares how retinal and V1 neural populations encode visual features, finding discrete encoding in retina and continuous in V1, with CNNs resembling retinal encoding.

This study shows that gene therapy for retinitis pigmentosa is most effective when administered before 50% rod loss, as later treatment fails to restore normal retinal function.

This paper introduces a 1-photon light-sheet microscopy system for high-throughput, high-resolution functional analysis of retinal neurons.

The paper shows that cones and their retinal pathways remain functional in advanced retinal degeneration, even as cones lose their outer-segment structures.

The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.

This study shows that cone-mediated signaling remains robust in retinal ganglion cells despite rod photoreceptor degeneration, suggesting gene therapies may still effectively preserve vision.