Miranda L. Scalabrino

This study shows that gene therapy for retinitis pigmentosa is most effective when administered before 50% rod loss, as later treatment fails to restore normal retinal function.

This paper introduces a 1-photon light-sheet microscopy system for high-throughput, high-resolution functional analysis of retinal neurons.

The paper shows that cones and their retinal pathways remain functional in advanced retinal degeneration, even as cones lose their outer-segment structures.

The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.

This study shows that cone-mediated signaling remains robust in retinal ganglion cells despite rod photoreceptor degeneration, suggesting gene therapies may still effectively preserve vision.