Author

Maria Cristina Morganti-Kossmann

Barrow Neurological InstituteORCID 0000-0002-0807-2063Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

Florian olde HeuveliD· 4 shared Francesco RoselliiD· 4 shared Rida RehmaniD· 4 shared Tobias M. BoeckersiD· 4 shared Albert Christian LudolphiD· 3 shared Albrecht Fröhlich· 3 shared Alison ConquestiD· 3 shared Markus Stefan Huber-LangiD· 3 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersNeuroscience

Florian olde HeuvelORCID

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Author profile →

4 papers

Recent·Most cited

The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

Rida Rehman, Albrecht Fröhlich, Florian olde Heuvel, Lobna Elsayed, Tobias M. Boeckers, Markus Stefan Huber-Lang, Maria Cristina Morganti-Kossmann, Francesco Roselli

This study shows that FGFR inhibition with Rogaratinib reduces microglia reactivity and synaptic loss in TBI by dampening neuroimmunological responses.

Frontiers in Immunology · Nov 20, 2024Peer-reviewedNeuroscience

Met/HGFR triggers detrimental reactive microglia in TBI

Rida Rehman, Michael Miller, Sruthi Sankari Krishnamurthy, Jacob Kjell, Lobna Elsayed, Stefanie M. Hauck, Florian olde Heuvel, Alison Conquest, Akila Chandrasekar, Albert Christian Ludolph, Tobias M. Boeckers, Medhanie Assmelash Mulaw, Magdalena Goetz, Maria Cristina Morganti-Kossmann, Aya Takeoka, Francesco Roselli

This study identifies cMet/HGFR as a modulator of early neuroinflammation in TBI, showing that its inhibition reduces microglial reactivity and improves recovery.

Cell Reports · Dec 1, 2022Peer-reviewedNeuroscience

Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Albrecht Fröhlich, Florian olde Heuvel, Rida Rehman, Sruthi Sankari Krishnamurthy, Shun Li, Zhenghui Li, David Bayer, Alison Conquest, Anna M. Hagenston, Albert Christian Ludolph, Markus Stefan Huber-Lang, Tobias M. Boeckers, Bernd Knöll, Maria Cristina Morganti-Kossmann, Hilmar Bading, Francesco Roselli

This study shows that reducing neuronal nuclear calcium signaling after TBI increases microglial reactivity and synaptic loss, mediated by osteoprotegerin.

Journal of Neuroinflammation · Nov 19, 2022Peer-reviewedNeuroscience

Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

Shun Li, Florian olde Heuvel, Rida Rehman, Zhenghui Li, Oumayma Aousji, Albrecht Fröhlich, Wanhong Zhang, Alison Conquest, Sarah Woelfle, Michael Schoen, Caitlin Claire O'Meara, Richard Lee Reinhardt, David Voehringer, Jan Kassubek, Albert Christian Ludolph, , Francesco Roselli

The paper identifies IL-13 and its receptor as neuronal synaptic proteins that enhance synaptic activity and neuroprotection in response to injury.

bioRxiv · Dec 1, 2021 · PreprintNeuroscience